Formulation Of Loose Powder Preparation And Evaluation Of The Anti-Fungal Activity Of The Ethanol Extract Of Water Pacar Leaves (Impatiens balsamina L) Against Candidiasis

Abstract

Henna leaves are a plant that can be used to cure various diseases. Henna leaves contain chemical compounds that are important for skin health, including alkaloids, flavonoids, saponins, tannins and steroids which have antifungal potential. This study aims to determine the physical characteristics and antifungal activity of a loose powder preparation of ethanol extract of henna leaves (Impatiens balsamina L) against the growth of the fungus Candida albicans. Laboratory experimental is a type of this research. Extraction of chemical compounds used the maceration method with 96% ethanol solvent which produced a thick extract of 45 grams. The thick extract is formulated into loose powder preparations with extract concentrations of 6.25%, 12.5% and 25%. The evaluation of the preparation includes organoleptic tests, pH, homogeneity, degree of smoothness, adhesion and Cycling test. The antifungal activity test used measurement of the diameter of the inhibition zone using the well method. Data analysis for testing physical characteristics and antifungal activity was carried out using Post Hoc LSD (sig. p<0.05). The results of this study indicate that the ethanol extract of henna leaves (Impatiens balsamina L) loose powder preparation meets the requirements for the physical characteristics of the preparation. The ethanol extract of henna leaves has antifungal activity against Candida albicans with an extract concentration of 6.25% producing an inhibitory zone diameter of 7.3 mm, a concentration of 12.5% producing an inhibitory zone diameter of 11.6 mm and a concentration of 25% producing the diameter of the inhibition zone was 15.4 mm, where FII and FIII were significantly different from the positive control (p<0.05). Loose powder formulations containing ethanol extract of henna leaves can be used as a treatment for skin diseases caused by the fungus Candida albicans.