Anti-inflammatory effects of Ethanol Extract of Cymbopogon nardus Herb on Rats Induced By Carrageenan

Abstract

Cymbopogon nardus contains many active compounds that are useful in inhibiting the inflammatory process. This study aims to determine the anti-inflammatory effect of ethanol extract of Cymbopogon nardus herb on male rats induced by carrageenan. Ethanol extract of Cymbopogon nardus herb was obtained by maceration with 70% ethanol as solvent. Twenty five male wistar rats were used in this study. Animals were divided into 5 group: namely the control group positive (diclofenac sodium 50 mg/kg BW), negative control (Na-CMC 1 %), and three doses of tested extract, namely 200 mg/kg BW, 400 mg/kg BW and 800 mg/kg BW. The method used in this study was paw edema, namely sixty minutes after treatment, all rats were injected by 0.1 mL of 1% carrageenan subplantarly on the rat's right paw. Paw volumes were measured by a plethysmometer every 60 minutes for 360 minutes, obtained data in the form of the volume of edema, Area Under the Curve (AUC), and percentage of power anti-inflammatory. The results showed that the AUC of ethanol extract of Cymbopogon nardus herb at doses of 200 mg/kg BW, 400 mg/kg BW, 800 mg/kg BW was significantly smaller than the negative control (p < 0.05), it can be concluded that the ethanol extract of Cymbopogon nardus herb has an anti-inflammatory effect on rats induced by carrageenan. The highest percentage of anti-inflammatory power was obtained at a dose of 400 mg/kg BW. Ethanol extract of Cymbopogon nardus herb contains flavonoids, alkaloids, tannins, and saponins.